P53 In The Clinics

Author: Pierre Hainaut
Publisher: Springer Science & Business Media
ISBN: 1461436761
Size: 34.92 MB
Format: PDF, ePub, Docs
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This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative ...

Lung Cancer An Issue Of Clinics In Chest Medicine

Author: Lynn T. Tanoue
Publisher: Elsevier Health Sciences
ISBN: 1455709719
Size: 42.33 MB
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5).159 p53 inactivating mutations are the most common alterations in lung cancer
, whereby 17p13 frequently demonstrates hemizygous deletion and mutational
inactivation in the remaining allele.160–162 Some point mutations in TP53
confer a gain-of-function phenotype leading to increased aggressiveness of lung
cancer.163 Due to the prevalence of p53 inactivating mutations in human
cancers, largescale efforts have been focused on therapeutic strategies to restore
normal p53 ...

Molecular Oncology An Issue Of Surgical Pathology Clinics

Author: Jennifer Hunt
Publisher: Elsevier Health Sciences
ISBN: 1455750530
Size: 28.44 MB
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Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a
marker for disease progression. J Natl Cancer Inst 1993;85:53–9. Sarkis AS,
Dalbagni G, Cordon-Cardo C, et al. Association of P53 nuclear overexpression
and tumor progression in carcinoma in situ of the bladder. J Urol 1994;152:388–
92. Sarkis AS, Bajorin DF, Reuter VE, et al. Prognostic value of p53 nuclear
overexpression in patients with invasive bladder cancer treated with neoadjuvant

Pediatric Otolaryngology Challenges In Multi System Disease An Issue Of Otolaryngologic Clinics

Author: Austin Rose
Publisher: Elsevier Health Sciences
ISBN: 1455744247
Size: 29.99 MB
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Molecular transformation of recurrent respiratory papillomatosis: viral typing and
p53 overexpression. AnnOtol Rhinol Laryngol.2003;112(4):298-302. 22. C.S.
Miller,B.M.Johnstone. Humanpapillomavirusasarisk factor for oral squamous cell
carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod. 2001;91(6):622-635. 23. E.M. Smith,S.S.Pignatari, S.D.Gray,etal.
Human papillomavirus infection in papillomas andnondiseased
respiratorysitesofpatients ...

Advances In Neurologic Therapy An Issue Of Neurologic Clinics

Author: José Biller
Publisher: Elsevier Health Sciences
ISBN: 1455700444
Size: 62.87 MB
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The intensity of GFAP staining with gliomas tends to increase with increasing
malignancy. Astrocytomas may also stain positive for other markers such as
vimentin.12 Vimentin is an intermediate filament expressed by cells during early
development; in particular neural crest-derived cells such as glial cells and
melanocytes express this marker. The common genetic abnormality seen with
low-grade astrocytomas is loss of heterozygosity (LOH) of 17p in the form p53
mutations.6,12,16 ...

Immunotherapy An Issue Of Neurosurgery Clinics

Author: Isaac Yang
Publisher: Elsevier Health Sciences
ISBN: 1455700452
Size: 68.50 MB
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Hsp70 is normally transcriptionally repressed by p53 binding of transcription
factors including NF-Y and (CCAATT binding factor) CBF.39,98,100 Absence of
p53 caused by TP53 mutations results in the lack of normal defenses against
tumorigenesis, and studies have demonstrated that Hsp70 binds mutant p53 and
accumulates abnormally in tumor cells of various cancers.39,101–103 One of the
mechanisms by which Hsp70 may be exerting its antiapoptotic protection of
cancer cells ...

Human Tumor Derived P53 Mutants A Growing Family Of Oncoproteins

Author: Ygal Haupt
Publisher: Frontiers Media SA
ISBN: 2889199614
Size: 79.56 MB
Format: PDF, Kindle
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MCT-12-1166 SobhaniM, Abdi J, Manujendra SN, Chen C, Chang H. PRIMA-
1Met induces apoptosis in Waldenstrom's Macroglobulinemia cells independent
of p53. Cancer Biol Ther (2015) 16:799–806. doi:10.1080/15384047.2015.
1026482 Piantino CB, Reis ST, Viana NI, Silva IA, Morais DR, Antunes AA, et al.
Prima-1 induces apoptosis in bladder cancer cell lines by activating p53. Clinics (
2013) 68:297–303. doi:10.6061/clinics/2013(03)OA03 Shalom-Feuerstein R,
Serror L, ...

Laparoscopic Approaches In Oncology An Issue Of Surgical Oncology Clinics

Author: James W. Fleshman Jr.
Publisher: Elsevier Health Sciences
ISBN: 1455747734
Size: 33.55 MB
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Oncologist. 2008;13(5):548–561. 43. M.L. Brandi, R.F. Gagel, A. Angeli, et al.
Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol
Metab. 2001;86(12):5658–5671. 44. H. Ohgaki, P. Kleihues, P.U. Heitz. p53
mutations in sporadic adrenocortical tumors. Int J Cancer. 1993;54(3):408–410.
45. M. Reincke, M. Karl, W.H. Travis, et al. p53 mutations in human adrenocortical
neoplasms: immunohistochemical and molecular studies. J Clin Endocrinol
Metab. 1994 ...

Gynecologic Cancer An Issue Of Hematology Oncology Clinics Of North America

Author: Ross S. Berkowitz
Publisher: Elsevier Health Sciences
ISBN: 1455742856
Size: 78.86 MB
Format: PDF
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1976;294(23):1259-1262. 64. M.F. Fathalla. Incessant ovulation—a factor in
ovarian neoplasia? Lancet. 1971;2(7716):163. 65. J.M. Schildkraut, E. Bastos, A.
Berchuck. Relationship between lifetime ovulatory cycles and overexpression of
mutant p53 in epithelial ovarian cancer. J Natl Cancer Inst. 1997;89(13):932-938.
66. A. Saleemuddin,A.K.Folkins,L. Garrett, et al. Risk factors for a serous cancer
precursor (“p53 signature”) in women withinherited BRCA mutations. Gynecol

Testes Cancer An Issue Of Hematology Oncology Clinics Of North America

Author: Timothy Gilligan
Publisher: Elsevier Health Sciences
ISBN: 1455712566
Size: 25.40 MB
Format: PDF, ePub
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J Clin Oncol. 2009;27:5240-5247. 58. M.I. Aladjem, B.T. Spike, L.W. Rodewald, et
al. ES cells do not activate p53- dependent stress responses and undergo p53-
independent apoptosisin response to DNA damage. Curr Biol. 1998;8:145-155.
59. Y. Hong, P.J. Stambrook. Restoration of an absent G 1 arrest and protection
from apoptosisin embryonic stemcells after ionizingradiation. ProcNatl Acad
SciUSA. 2004;101:14443-14448. 60. J.W. Oosterhuis, P.W. Andrews,B.B.