P53 In The Clinics

Author: Pierre Hainaut
Publisher: Springer Science & Business Media
ISBN: 1461436761
Size: 14.71 MB
Format: PDF
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This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative ...

Cytopathology An Issue Of Surgical Pathology Clinics

Author: Tarik El Sheikh
Publisher: Elsevier Health Sciences
ISBN: 0323261337
Size: 24.21 MB
Format: PDF
View: 2867
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Reactive ductal cells are negative for p53, maspin, S100P, and IMP-3 and
positive for Dpc4 and PDA is positive for p53, maspin, S100P, and IMP-3;
negative for Dpc4 and pVHL; and negative or PDA shows somatic mutations of K-
RAS, ...

Lung Cancer An Issue Of Clinics In Chest Medicine

Author: Lynn T. Tanoue
Publisher: Elsevier Health Sciences
ISBN: 1455709719
Size: 59.75 MB
Format: PDF, ePub
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Ad.p53 Given that wild-type p53 protein has a brief half-life and is therefore
present in low levels in normal cells, whereas mutant p53 has a significantly
prolonged half-life and is present in greater quantities in tumor cells, p53 protein
has been ...

Photodermatology An Issue Of Dermatologic Clinics

Author: Henry Lim
Publisher: Elsevier Health Sciences
ISBN: 0323311806
Size: 41.12 MB
Format: PDF, Mobi
View: 2560
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This is accomplished through p53, a tumor suppressor gene that plays a central
role in cell repair, apoptosis, and cell-cycle arrest to Fig. 1. Mechanisms of UV-
induced photocarcinogenesis. allow time for repairs. The levels of p53 are ...

Breast Cancer An Issue Of Surgical Oncology Clinics Of North America

Author: Lisa Newman
Publisher: Elsevier Health Sciences
ISBN: 032331192X
Size: 70.57 MB
Format: PDF, ePub, Docs
View: 4822
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BRCA2 cancers are also usually HER2-negative, but tend to be ER/PR-positive.
59 P53/Li-Fraumeni syndrome P53 is another high-penetrance gene with a
proven link to breast cancer. Mutations in P53 are associated with Li-Fraumeni ...

Molecular Oncology An Issue Of Surgical Pathology Clinics

Author: Jennifer Hunt
Publisher: Elsevier Health Sciences
ISBN: 1455750530
Size: 20.80 MB
Format: PDF, Docs
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Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a
marker for disease progression. J Natl Cancer Inst 1993;85:53–9. Sarkis AS,
Dalbagni G, Cordon-Cardo C, et al. Association of P53 nuclear overexpression
and ...

Pediatric Hematology An Issue Of Pediatric Clinics

Author: Catherine S. Manno
Publisher: Elsevier Health Sciences
ISBN: 0323261191
Size: 59.12 MB
Format: PDF, Docs
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As noted earlier, increased understanding of DBA came through amelioration of
its phenotype in a p53 knockout background in both the mouse and the zebrafish,
leading to a lower rate of apoptosis and suggesting that the imbalance of ...

Molecular Pathology An Issue Of Clinics In Laboratory Medicine

Author: Martin H. Bluth
Publisher: Elsevier Health Sciences
ISBN: 0323261051
Size: 11.30 MB
Format: PDF, Docs
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Abnormally produced C-MYC activates a protective pathway through the
induction of p53-dependent cell death pathway, among others, such as p14ARF
and BCL-2 like protein11 (BIM), which forces such cells to undergo apoptosis.
p53 plays ...