P53 In The Clinics

Author: Pierre Hainaut
Publisher: Springer Science & Business Media
ISBN: 1461436761
Size: 57.99 MB
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This book thus captures a critical turning point in p53 research, from basic to translational research and clinical application. p53 in the Clinics follows the success of 25 Years of p53 Research and condensates in a series of authoritative ...

Lung Cancer An Issue Of Clinics In Chest Medicine

Author: Lynn T. Tanoue
Publisher: Elsevier Health Sciences
ISBN: 1455709719
Size: 67.44 MB
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5).159 p53 inactivating mutations are the most common alterations in lung cancer
, whereby 17p13 frequently demonstrates hemizygous deletion and mutational
inactivation in the remaining allele.160–162 Some point mutations in TP53
confer a gain-of-function phenotype leading to increased aggressiveness of lung
cancer.163 Due to the prevalence of p53 inactivating mutations in human
cancers, largescale efforts have been focused on therapeutic strategies to restore
normal p53 ...

Photodermatology An Issue Of Dermatologic Clinics

Author: Henry Lim
Publisher: Elsevier Health Sciences
ISBN: 0323311806
Size: 54.99 MB
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This is accomplished through p53, a tumor suppressor gene that plays a central
role in cell repair, apoptosis, and cell-cycle arrest to Fig. 1. Mechanisms of UV-
induced photocarcinogenesis. allow time for repairs. The levels of p53 are
increased in normal keratinocytes after UVR exposure.6 If the p53 gene is
mutated, the cell may not be able to repair itself, leading to permanent damage.
The cell may also become resistant to apoptosis.8 P53 mutations have been
demonstrated in ...

Cytopathology An Issue Of Surgical Pathology Clinics

Author: Tarik El Sheikh
Publisher: Elsevier Health Sciences
ISBN: 0323261337
Size: 39.33 MB
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Reactive ductal cells are negative for p53, maspin, S100P, and IMP-3 and
positive for Dpc4 and PDA is positive for p53, maspin, S100P, and IMP-3;
negative for Dpc4 and pVHL; and negative or PDA shows somatic mutations of K-
RAS, p16/CDKN2A, p53, and DPC4/SMAD4, which are not seen Duodenal
epithelium forms sheets of columnar cells with interspersed goblet cells and has
an asso Duodenal epithelium is positive for CDX2 and Dpc4 but negative for p53

Molecular Oncology An Issue Of Surgical Pathology Clinics

Author: Jennifer Hunt
Publisher: Elsevier Health Sciences
ISBN: 1455750530
Size: 40.50 MB
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Nuclear overexpression of p53 protein in transitional cell bladder carcinoma: a
marker for disease progression. J Natl Cancer Inst 1993;85:53–9. Sarkis AS,
Dalbagni G, Cordon-Cardo C, et al. Association of P53 nuclear overexpression
and tumor progression in carcinoma in situ of the bladder. J Urol 1994;152:388–
92. Sarkis AS, Bajorin DF, Reuter VE, et al. Prognostic value of p53 nuclear
overexpression in patients with invasive bladder cancer treated with neoadjuvant

Pediatric Otolaryngology Challenges In Multi System Disease An Issue Of Otolaryngologic Clinics

Author: Austin Rose
Publisher: Elsevier Health Sciences
ISBN: 1455744247
Size: 76.99 MB
Format: PDF
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Molecular transformation of recurrent respiratory papillomatosis: viral typing and
p53 overexpression. AnnOtol Rhinol Laryngol.2003;112(4):298-302. 22. C.S.
Miller,B.M.Johnstone. Humanpapillomavirusasarisk factor for oral squamous cell
carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod. 2001;91(6):622-635. 23. E.M. Smith,S.S.Pignatari, S.D.Gray,etal.
Human papillomavirus infection in papillomas andnondiseased
respiratorysitesofpatients ...

Breast Cancer An Issue Of Surgical Oncology Clinics Of North America

Author: Lisa Newman
Publisher: Elsevier Health Sciences
ISBN: 032331192X
Size: 19.31 MB
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BRCA2 cancers are also usually HER2-negative, but tend to be ER/PR-positive.
59 P53/Li-Fraumeni syndrome P53 is another high-penetrance gene with a
proven link to breast cancer. Mutations in P53 are associated with Li-Fraumeni
syndrome (LFS), which carries an increased risk of breast cancer as well as
leukemia and malignancies of the lung and brain.60 Women with LFS have a 50
% risk of breast cancer by age 60.61 LFS and P53-associated malignancies may
account for ...

Molecular Pathology An Issue Of Clinics In Laboratory Medicine

Author: Martin H. Bluth
Publisher: Elsevier Health Sciences
ISBN: 0323261051
Size: 78.57 MB
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Malabsorption with diarrhea and malodorous, greasy stools may also be present.
2 Pathophysiology and Molecular Genetics Ductal adenocarcinoma The most
common genetic changes seen in ductal adenocarcinoma seen in decreasing
order of frequency include KRAS codon 12 mutations seen in 90%, loss of
Smad4 (DPC4) in 55%,3,4 and TP53 mutations seen in 50% of cases.5
Alterations in pancreatic intraepithelial neoplasias include KRAS (early stages),
p16 (middle), and ...

Pediatric Hematology An Issue Of Pediatric Clinics

Author: Catherine S. Manno
Publisher: Elsevier Health Sciences
ISBN: 0323261191
Size: 34.63 MB
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As noted earlier, increased understanding of DBA came through amelioration of
its phenotype in a p53 knockout background in both the mouse and the zebrafish,
leading to a lower rate of apoptosis and suggesting that the imbalance of
ribosome synthesis or inefficiency of protein translation leads to cell stress. In
addition, RPS26 has been shown through an RPL11-mediated pathway to
stabilize p53 via interaction in an inhibitory fashion with MDM2, which is the E3
ubiquitin ligase for ...

Immunotherapy An Issue Of Neurosurgery Clinics

Author: Isaac Yang
Publisher: Elsevier Health Sciences
ISBN: 1455700452
Size: 49.12 MB
Format: PDF, Docs
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Hsp70 is normally transcriptionally repressed by p53 binding of transcription
factors including NF-Y and (CCAATT binding factor) CBF.39,98,100 Absence of
p53 caused by TP53 mutations results in the lack of normal defenses against
tumorigenesis, and studies have demonstrated that Hsp70 binds mutant p53 and
accumulates abnormally in tumor cells of various cancers.39,101–103 One of the
mechanisms by which Hsp70 may be exerting its antiapoptotic protection of
cancer cells ...