Process Scale Purification Of Antibodies

Author: Uwe Gottschalk
Publisher: John Wiley & Sons
ISBN: 1119126932
Size: 28.70 MB
Format: PDF
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Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates ...

Continuous Processing In Pharmaceutical Manufacturing

Author: Ganapathy Subramanian
Publisher: John Wiley & Sons
ISBN: 3527335951
Size: 63.25 MB
Format: PDF, Docs
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With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes.

Scale Up And Optimization In Preparative Chromatography

Author: Anurag Rathore
Publisher: CRC Press
ISBN: 082474358X
Size: 47.19 MB
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This text offers fundamental analysis of the underlying physicochemical principles to select optimal modes of interaction, design efficient separations, and increase productivity in the manufacture of novel therapeutics and pharmaceuticals.

Process Scale Bioseparations For The Biopharmaceutical Industry

Author: Abhinav A. Shukla
Publisher: CRC Press
ISBN: 1420016024
Size: 15.43 MB
Format: PDF
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Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations ...

Bioseparations Science And Engineering

Author: Roger G. Harrison
Publisher: Oxford University Press
ISBN: 0190213744
Size: 52.10 MB
Format: PDF, ePub
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method is that low levels of Protein A or its fragments coelute with the antibody.
However, trace amounts of this contaminant and others such as high molecular
weight aggregates of the antibody and hostcell protein can be removed in one or
two subsequent chromatography steps. More information about the process scale
purification of monoclonal antibodies using Protein A is found in “Therapeutic
Monoclonal Antibody Production” (Section 12.6.3). 7.7.7 Immobilized Metal
Affinity ...

Disposable Bioprocessing Systems

Author: Sarfaraz K. Niazi
Publisher: CRC Press
ISBN: 1439866708
Size: 15.75 MB
Format: PDF, ePub
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Biotechnol. Prog. 22: 341-349. Zhou, ].X., Solamo, F., Hong, T., Shearer, M., and
Tressel, T. 2008. Viral clearance using disposable systems in monoclonal
antibody commercial downstream processing. Biotechnol. Bioeng. 100: 488-496.
Zhou, ].X., Tressel, T., Gottschalk, U., Solamo, F., Pastor, A., Dermawan, S., Hong,
T., Reif, O.W., Mora, ]., Hutchinson, F., and Murphy, M. 2006. New Q membrane
scale-down model for process-scale antibody purification. }. Chromatogr. A I 134:

Vaccine Development And Manufacturing

Author: Emily P. Wen
Publisher: John Wiley & Sons
ISBN: 1118870905
Size: 14.64 MB
Format: PDF, ePub, Docs
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Technical and economical evaluation of downstream processing options for
monoclonal antibody (Mab) production. BioPharm Int2006 ... PREPTECH 2003
Process Scale Separation Technology in the Manufacturing of (Bio)-
Pharmaceuticals; July 7–9; Germany: Dorint Hotel, Quellenhof, AACHEN; 2003.
Langer ES. ... Larson TM, Davis J, Lam H, Cacia J. Use of process data to assess
chromatographic performance in production-scale protein purification columns.
Biotechnol Prog ...


Author: Charles A. Janeway
Publisher: Spektrum Akademischer Verlag
ISBN: 9783827410795
Size: 56.18 MB
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Der "Janeway" bleibt damit ein hochaktueller und verlässlicher Begleiter in diesem unverändert rasant fortschreitenden Fachgebiet. ”In seiner 5. Auflage wird Immunologie auf den Ranglisten weiter hinaufklettern.

Hplc Of Biological Macromolecules

Author: Karen M. Gooding
Publisher: Marcel Dekker Incorporated
ISBN: 9780824778798
Size: 19.77 MB
Format: PDF, ePub, Docs
View: 2002
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It is also a good choice for preparative purification if one can tolerate small
quantities of transferrin in the sample and the relatively small sample volume
which can be purified by a single column run. If there is no ... After a detailed
review of the literature, a "recommended" procedure for purifying antibodies from
ASF or TCS can be suggested. If at all ... Within the last 3 years (1987-1989) a
number of studies on large and process scale purification of antibodies have
been described.